There is no wrong way to drive Route 66, whether it’s from end to end or you start somewhere in the middle. An important thing to note when driving Route 66 is that not the entire road is still drivable. There may be a few times you will have to divert back to the interstate and follow signs for when the original route picks back up. But for now, let’s talk about the sites, experiences and adventures that await you on “The Mother Road.”

The Florida Keys have been an iconic vacation destination for multiple decades and each of these unique islands have their own personal charms that are just waiting to be discovered. From Key Largo to Key West and everything in between, this itinerary is designed to aid in planning the best weekend road trip down the Overseas Highway.